Online PrEP & PEP Care in Sioux Falls, SD
Protect your health with confidential HIV prevention care from the privacy of home. PrEP for ongoing protection. PEP if you've had a recent possible exposure.
Affordable PrEP Care From Home
Visits Starting At
$99
Meet online with a licensed provider to discuss whether PrEP is right for you.
PrEP Medication Starting As Low As
$13/Month*
Eligible prescriptions may have low-cost PrEP options available.
Discreet Delivery
Delivered to Your Home
When available, we ship your medication in discreet packaging.
100% Online
From Evaluation to Follow-Up
Private care from start to finish.
*Medication pricing varies based on medication, pharmacy, insurance coverage and other factors. $13/month reflects the lowest available cash-price option for eligible prescriptions and is not guaranteed for every patient. Delivery availability may vary.
PrEP and PEP Protect You at Different Times
Before Exposure
Daily Prevention
Daily prevention for people who don't have HIV. Reduces risk of getting HIV from sex by about 99% when taken as prescribed.
Learn About PrEPAfter Possible Exposure
Emergency Medication
Emergency medication taken after a possible HIV exposure. Must start as soon as possible – ideally within 24 hours.
Learn About PEP72 Hours
PEP Window
PEP should be started as soon as possible after exposure and no later than 72 hours.
28 Days
Complete the Course
When prescribed, PEP is taken for 28 days for maximum protection.
PrEP and PEP help prevent HIV. They do not prevent pregnancy or other sexually transmitted infections.
Need PEP? Act Quickly.
If you think you've been exposed to HIV, don't wait. PEP should be started as soon as possible — ideally within 24 hours and no later than 72 hours after exposure.
Every hour matters.
At this time, we provide PEP services in select cases and limited hours. This program is intended for non-emergency care only. Individuals requiring urgent evaluation after a recent high-risk exposure or sexual assault should seek immediate in-person medical care or emergency services.
PrEP Care for Sioux Falls Residents
We provide 100% online PrEP care to eligible patients in Sioux Falls and surrounding communities.
Areas Served
- Downtown Sioux Falls
- East Side
- West Side
- South Side
- Brandon
- Harrisburg
- Tea
- Crooks
- Renner
- Baltic
- Garretson
- More Communities
Why Sioux Falls Chooses DevotedDoc
- 100% online – no clinics or waiting rooms
- Affordable visits starting at $99
- PrEP medication as low as $13/month*
- Discreet delivery to your home
- Insurance accepted & payment options available
You May Benefit From PrEP If:
Anyone who wants more control over their HIV prevention can talk to a healthcare provider about PrEP.
Your PrEP Care Includes:
Medical Evaluation
Online visit with a licensed provider.
HIV & STI Testing
We coordinate the appropriate testing.
Lab Monitoring
Ongoing labs to keep you safe on PrEP.
PrEP Prescription
When appropriate, your provider will prescribe PrEP.
Medication Delivery
Discreet delivery when available.
Ongoing Follow-Up
Refills, support, and continued care.
The Numbers Show Why Prevention Matters
Data below reflects statewide South Dakota totals — South Dakota does not publish HIV diagnosis counts, rates, or prevalence at the city or county level.
36
New HIV Diagnoses
People newly diagnosed with HIV or AIDS statewide in South Dakota (2024).
3.9
Diagnosis Rate
New HIV diagnoses per 100,000 people, statewide South Dakota (2024).
860
People Living With HIV
People with HIV and/or AIDS known to be living in South Dakota as of December 31, 2024.
Not Ranked
Highest Rates in SD
South Dakota does not calculate or publish a county-by-county HIV diagnosis rate ranking; case counts in most counties are too small to report individually without risking patient identification.
Source: South Dakota Department of Health, 2025 HIV/AIDS Surveillance Report (data as of Feb. 2025, covering diagnoses through Dec. 31, 2024). Data provisional. View South Dakota HIV Data
Simple Steps to Protection
Schedule
Book your online appointment in minutes.
Meet
Talk with a licensed provider about your needs and goals.
Test & Treat
Complete testing. Get PrEP or PEP if medically appropriate.
Get Medication
We send your medication discreetly to your home when available.
Follow Up
Continue care, refills, and ongoing support.
Frequently Asked Questions
Cost depends on your insurance coverage and eligibility for assistance programs. Many patients pay little to nothing out of pocket — our team will review your options during your visit.
Yes. DevotedDoc offers online evaluations, testing coordination, and prescriptions for Sioux Falls-area patients from the comfort of home.
Yes. Uninsured patients can often access manufacturer assistance programs, state resources, or our affordable self-pay options.
Most patients complete their online visit and lab coordination within a few days and can begin PrEP shortly after results are reviewed.
Yes. If you’ve had a possible exposure, start an online visit as soon as possible. PEP is most effective when started within 72 hours.
Absolutely. All visits, labs, and prescriptions are handled with strict confidentiality and discreet delivery options.
Take Control of Your HIV Prevention
PrEP visits start at $99. Get confidential, expert care from home.
Start Your Visit – From $99